Spider-Man has been fighting crime for over 50 years…and he’s made a few enemies along the way. Here’s a look back at over 100 Spider-Man foes from the Sinister Six to Kingpin to the Goblin Underground to Hypno-Hustler. A lot can change in 50 years: costumes, motivations, allegiances, code names, secret identities and more. One things for sure: as long as there’s a Spider-Man, he’ll have villains.

Many Villains of Spider-Man Infographic
Many Villains of Spider-Man
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